dc.contributor.authorHu, Benhui
dc.contributor.authorLeow, Wan Ru
dc.contributor.authorAmini, Shahrouz
dc.contributor.authorNai, Brenda
dc.contributor.authorZhang, Xiaoqian
dc.contributor.authorLiu, Zhiyuan
dc.contributor.authorCai, Pingqiang
dc.contributor.authorLi, Zhuyun
dc.contributor.authorWu, Yun-Long
dc.contributor.authorMiserez, Ali
dc.contributor.authorLim, Chwee Teck
dc.contributor.authorChen, Xiaodong
dc.identifier.citationHu, B., Leow, W. R., Amini, S., Nai, B., Zhang, X., Liu, Z., et al. (2017). Orientational Coupling Locally Orchestrates a Cell Migration Pattern for Re-Epithelialization. Advanced Materials, in press.en_US
dc.description.abstractRe-epithelialization by collective migration of epithelial cells over a heterogeneous environment to restore tissue integrity and functions is critical for development and regeneration. Here, it is reported that the spatial organization of adjacent adherent paths within sparsely distributed extracellular matrix (ECM) has a significant impact on the orientational coupling between cell polarization and collective cell migration. This coupling effect determines the migration pattern for human keratinocytes to regain their cohesion, which impacts the occupancy of epithelial bridge and the migration velocity in wound repair. Statistical studies suggest the converging organization of ECM, in which adjacent paths become closer to each other and finally converge to a junctional point, facilitating collective cell migration mostly within variable ECM organization, as the polarization of the advancing cell sheet is remodeled to align along the direction of cell migration. The findings may help to design implantable ECM to optimize efficient skin regeneration.en_US
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en_US
dc.format.extent28 p.
dc.relation.ispartofseriesAdvanced Materialsen_US
dc.rights© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the author created version of a work that has been peer reviewed and accepted for publication by Advanced Materials, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1002/adma.201700145].en_US
dc.subjectEpithelial bridgeen_US
dc.subjectMigration patternsen_US
dc.titleOrientational Coupling Locally Orchestrates a Cell Migration Pattern for Re-Epithelializationen_US
dc.typeJournal Article
dc.contributor.researchInnovative Centre for Flexible Devicesen_US
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.description.versionAccepted version

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