dc.contributor.authorGoh, H. M. Sharon
dc.contributor.authorYong, M. H. Adeline
dc.contributor.authorChong, Kelvin Kian Long
dc.contributor.authorKline, Kimberly A.
dc.identifier.citationGoh, H. M. S., Yong, M. H. A., Chong, K. K. L., & Kline, K. A. (2017). Model systems for the study of Enterococcal colonization and infection. Virulence, 1-38.en_US
dc.description.abstractEnterococcus faecalis and Enterococcus faecium are common inhabitants of the human gastrointestinal tract, as well as frequent opportunistic pathogens. Enterococci cause a range of infections including, most frequently, infections of the urinary tract, catheterized urinary tract, bloodstream, wounds and surgical sites, and heart valves in endocarditis. Enterococcal infections are often biofilm-associated, polymicrobial in nature, and resistant to antibiotics of last resort. Understanding Enterococcal mechanisms of colonization and pathogenesis are important for identifying new ways to manage and intervene with these infections. We review vertebrate and invertebrate model systems applied to study the most common E. faecalis and E. faecium infections, with emphasis on recent findings examining Enterococcal-host interactions using these models. We discuss strengths and shortcomings of each model, propose future animal models not yet applied to study mono- and polymicrobial infections involving E. faecalis and E. faecium, and comment on the significance of anti-virulence strategies derived from a fundamental understanding of host-pathogen interactions in model systems.en_US
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.format.extent38 p.en_US
dc.rights© 2017 The Author(s). Published with license by Taylor & Francis© H. M. Sharon Goh, M. H. Adeline Yong, Kelvin Kian Long Chong, and Kimberly A. Kline. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.en_US
dc.subjectAnimal Modelsen_US
dc.subjectEnterococcus faecalisen_US
dc.titleModel systems for the study of Enterococcal colonization and infectionen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.contributor.schoolInterdisciplinary Graduate School (IGS)en_US
dc.description.versionPublished versionen_US
dc.contributor.organizationSingapore Centre for Environmental Life Sciences Engineeringen_US

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