Thiophene-derived polymer dots for imaging endocytic compartments in live cells and broad-spectrum bacterial killing
Prasad, Kenath Priyanka
Alam SK, Mahasin
Date of Issue2017
School of Chemical and Biomedical Engineering
In this work, we present a new type of polymer dot synthesized from bithiophene (pTh-Pdot) via a simple and high yield procedure. Owing to their high brightness, excellent photo-stability, good biocompatibility, and molecular size, pTh-Pdots are promising for bioimaging applications. As a proof-of-concept demonstration, pTh-Pdots are herein employed to track the endocytic pathway in live cells. Furthermore, we show that these polymeric nanoparticles can serve as potent antibacterial agents by making use of their ability to disrupt bacterial membranes and high peroxidase mimicking activity.
Materials Chemistry Frontiers
© 2017 The Author(s). Published by The Royal Society of Chemistry and the Chinese Chemical Society. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.