dc.contributor.authorTan, Sijie
dc.contributor.authorWong, Esther
dc.date.accessioned2017-07-19T04:28:43Z
dc.date.available2017-07-19T04:28:43Z
dc.date.issued2017
dc.identifier.citationTan, S., & Wong, E. (2017). Mitophagy Transcriptome: Mechanistic Insights into Polyphenol-Mediated Mitophagy. Oxidative Medicine and Cellular Longevity, 2017, 9028435-.en_US
dc.identifier.issn1942-0900en_US
dc.identifier.urihttp://hdl.handle.net/10220/42930
dc.description.abstractMitochondria are important bioenergetic and signalling hubs critical for myriad cellular functions and homeostasis. Dysfunction in mitochondria is a central theme in aging and diseases. Mitophagy, a process whereby damaged mitochondria are selectively removed by autophagy, plays a key homeostatic role in mitochondrial quality control. Upregulation of mitophagy has shown to mitigate superfluous mitochondrial accumulation and toxicity to safeguard mitochondrial fitness. Hence, mitophagy is a viable target to promote longevity and prevent age-related pathologies. Current challenge in modulating mitophagy for cellular protection involves identification of physiological ways to activate the pathway. Till date, mitochondrial stress and toxins remain the most potent inducers of mitophagy. Polyphenols have recently been demonstrated to protect mitochondrial health by facilitating mitophagy, thus suggesting the exciting prospect of augmenting mitophagy through dietary intake. In this review, we will first discuss the different surveillance mechanisms responsible for the removal of damaged mitochondrial components, followed by highlighting the transcriptional regulatory mechanisms of mitophagy. Finally, we will review the functional connection between polyphenols and mitophagy and provide insight into the underlying mechanisms that potentially govern polyphenol-induced mitophagy.en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.format.extent13 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesOxidative Medicine and Cellular Longevityen_US
dc.rights© 2017 Sijie Tan and Esther Wong. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.subjectMitophagyen_US
dc.subjectPolyphenolen_US
dc.titleMitophagy Transcriptome: Mechanistic Insights into Polyphenol-Mediated Mitophagyen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.identifier.doihttp://dx.doi.org/10.1155/2017/9028435
dc.description.versionPublished versionen_US
dc.identifier.rims199949


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