dc.contributor.authorMakino, Hiroshi
dc.contributor.authorRen, Chi
dc.contributor.authorLiu, Haixin
dc.contributor.authorKim, An Na
dc.contributor.authorKondapaneni, Neehar
dc.contributor.authorLiu, Xin
dc.contributor.authorKuzum, Duygu
dc.contributor.authorKomiyama, Takaki
dc.date.accessioned2017-07-25T02:00:40Z
dc.date.available2017-07-25T02:00:40Z
dc.date.issued2017
dc.identifier.citationMakino, H., Ren, C., Liu, H., Kim, A. N., Kondapaneni, N., Liu, X., et al. (2017). Transformation of Cortex-wide Emergent Properties during Motor Learning. Neuron, 94(4), 880-890.e8.en_US
dc.identifier.issn0896-6273en_US
dc.identifier.urihttp://hdl.handle.net/10220/43426
dc.description.abstractLearning involves a transformation of brain-wide operation dynamics. However, our understanding of learning-related changes in macroscopic dynamics is limited. Here, we monitored cortex-wide activity of the mouse brain using wide-field calcium imaging while the mouse learned a motor task over weeks. Over learning, the sequential activity across cortical modules became temporally more compressed, and its trial-by-trial variability decreased. Moreover, a new flow of activity emerged during learning, originating from premotor cortex (M2), and M2 became predictive of the activity of many other modules. Inactivation experiments showed that M2 is critical for the post-learning dynamics in the cortex-wide activity. Furthermore, two-photon calcium imaging revealed that M2 ensemble activity also showed earlier activity onset and reduced variability with learning, which was accompanied by changes in the activity-movement relationship. These results reveal newly emergent properties of macroscopic cortical dynamics during motor learning and highlight the importance of M2 in controlling learned movements.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesNeuronen_US
dc.rights© 2017 Elsevier Inc.en_US
dc.subjectMotor learningen_US
dc.subjectWide-field calcium imagingen_US
dc.titleTransformation of Cortex-wide Emergent Properties during Motor Learningen_US
dc.typeJournal Article
dc.contributor.schoolLee Kong Chian School of Medicineen_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.neuron.2017.04.015


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