Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/84161
Title: | Progress in Understanding the Molecular Basis Underlying Functional Diversification of Cyclic Dinucleotide Turnover Proteins | Authors: | Römling, Ute Liang, Zhao-Xun Dow, J. Maxwell |
Keywords: | GGDEF domain Cyclic dinucleotide second messenger |
Issue Date: | 2017 | Source: | Römling, U., Liang, Z.-X., & Dow, J. M. (2017). Progress in Understanding the Molecular Basis Underlying Functional Diversification of Cyclic Dinucleotide Turnover Proteins. Journal of Bacteriology, 199(5), e00790-16-. | Series/Report no.: | Journal of Bacteriology | Abstract: | Cyclic di-GMP was the first cyclic dinucleotide second messenger described, presaging the discovery of additional cyclic dinucleotide messengers in bacteria and eukaryotes. The GGDEF diguanylate cyclase (DGC) and EAL and HD-GYP phosphodiesterase (PDE) domains conduct the turnover of cyclic di-GMP. These three unrelated domains belong to superfamilies that exhibit significant variations in function, and they include both enzymatically active and inactive members, with a subset involved in synthesis and degradation of other cyclic dinucleotides. Here, we summarize current knowledge of sequence and structural variations that underpin the functional diversification of cyclic di-GMP turnover proteins. Moreover, we highlight that superfamily diversification is not restricted to cyclic di-GMP signaling domains, as particular DHH/DHHA1 domain and HD domain proteins have been shown to act as cyclic di-AMP phosphodiesterases. We conclude with a consideration of the current limitations that such diversity of action places on bioinformatic prediction of the roles of GGDEF, EAL, and HD-GYP domain proteins. | URI: | https://hdl.handle.net/10356/84161 http://hdl.handle.net/10220/43568 |
ISSN: | 0021-9193 | DOI: | 10.1128/JB.00790-16 | Schools: | School of Biological Sciences | Rights: | © 2017 American Society for Microbiology (ASM). This paper was published in Journal of Bacteriology and is made available as an electronic reprint (preprint) with permission of American Society for Microbiology (ASM). The published version is available at: [http://dx.doi.org/10.1128/JB.00790-16]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | SBS Journal Articles |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Progress in Understanding the Molecular Basis Underlying Functional Diversification of Cyclic Dinucleotide Turnover Proteins.pdf | 5.69 MB | Adobe PDF | View/Open |
SCOPUSTM
Citations
10
40
Updated on Mar 27, 2024
Web of ScienceTM
Citations
10
33
Updated on Oct 25, 2023
Page view(s) 50
589
Updated on Mar 27, 2024
Download(s) 50
146
Updated on Mar 27, 2024
Google ScholarTM
Check
Altmetric
Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.