Place cells and long-term potentiation in the hippocampus
Cobar, Luis Fernando
Date of Issue2016
School of Biological Sciences
Place cells show location-specific firing patterns according to an animal’s position in an environment and are thought to contribute to the spatial representation required for self-navigation. Decades of study have extensively characterized the properties of place cells and suggested the involvement of long-term potentiation (LTP), a long-lasting synaptic strengthening, in place cell activity. Here, we review the basic characteristics of place cell activity and the findings that support the idea that LTP contributes to the formation, maintenance, and plasticity of place cell activity.
Neurobiology of Learning and Memory
© 2016 Elsevier. This is the author created version of a work that has been peer reviewed and accepted for publication by Neurobiology of Learning and Memory, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1016/j.nlm.2016.10.010].