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|Title:||Dendronized semiconducting polymer as photothermal nanocarrier for remote activation of gene expression||Authors:||Lyu, Yan
|Keywords:||Dendronized semiconducting polymer
|Issue Date:||2017||Source:||Lyu, Y., Cui, D., Sun, H., Miao, Y., Duan, H., & Pu, K. (2017). Dendronized Semiconducting Polymer as Photothermal Nanocarrier for Remote Activation of Gene Expression. Angewandte Chemie International Edition, 56(31), 9155-9159.||Series/Report no.:||Angewandte Chemie International Edition||Abstract:||Regulation of transgene systems is needed to develop innovative medicines. However, noninvasive remote control of gene expression has been rarely developed and remains challenging. We herein synthesize a near-infrared (NIR) absorbing dendronized semiconducting polymer (DSP) and utilize it as a photothermal nanocarrier not only to efficiently deliver genes but also to spatiotemporally control gene expression in conjunction with heat-inducible promoter. DSP has a high photothermal conversion efficiency (44.2 %) at 808 nm, permitting fast transduction of NIR light into thermal signals for intracellular activation of transcription. Such a DSP-mediated remote activation can rapidly and safely result in 25- and 4.5-fold increases in the expression levels of proteins in living cells and mice, respectively. This study thus provides a promising approach to optically regulate transgene systems for on-demand therapeutic transgene dosing.||URI:||https://hdl.handle.net/10356/84415
|ISSN:||1433-7851||DOI:||http://dx.doi.org/10.1002/anie.201705543||Rights:||© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the author created version of a work that has been peer reviewed and accepted for publication by Angewandte Chemie International Edition, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1002/anie.201705543].||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||SBS Journal Articles|
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