dc.contributor.authorJiang, Yuyan
dc.contributor.authorUpputuri, Paul Kumar
dc.contributor.authorXie, Chen
dc.contributor.authorLyu, Yan
dc.contributor.authorZhang, Lulu
dc.contributor.authorXiong, Qihua
dc.contributor.authorPramanik, Manojit
dc.contributor.authorPu, Kanyi
dc.date.accessioned2017-08-16T07:07:01Z
dc.date.available2017-08-16T07:07:01Z
dc.date.copyright2017
dc.date.issued2017
dc.identifier14 p.
dc.identifier.citationJiang, Y., Upputuri, P. K., Xie, C., Lyu, Y., Zhang, L., Xiong, Q., et al. (2017). Broadband Absorbing Semiconducting Polymer Nanoparticles for Photoacoustic Imaging in Second Near-Infrared Window. Nano Letters, 17(8), 4964-4969.en_US
dc.identifier.issn1530-6984en_US
dc.identifier.urihttp://hdl.handle.net/10220/43592
dc.description.abstractPhotoacoustic (PA) imaging holds great promise for preclinical research and clinical practice. However, most studies rely on the laser wavelength in the first near-infrared (NIR) window (NIR-I, 650–950 nm), while few studies have been exploited in the second NIR window (NIR-II, 1000–1700 nm), mainly due to the lack of NIR-II absorbing contrast agents. We herein report the synthesis of a broadband absorbing PA contrast agent based on semiconducting polymer nanoparticles (SPN-II) and apply it for PA imaging in NIR-II window. SPN-II can absorb in both NIR-I and NIR-II regions, providing the feasibility to directly compare PA imaging at 750 nm with that at 1064 nm. Because of the weaker background PA signals from biological tissues in NIR-II window, the signal-to-noise ratio (SNR) of SPN-II resulted PA images at 1064 nm can be 1.4-times higher than that at 750 nm when comparing at the imaging depth of 3 cm. The proof-of-concept application of NIR-II PA imaging is demonstrated in in vivo imaging of brain vasculature in living rats, which showed 1.5-times higher SNR as compared with NIR-I PA imaging. Our study not only introduces the first broadband absorbing organic contrast agent that is applicable for PA imaging in both NIR-I and NIR-II windows but also reveals the advantages of NIR-II over NIR-I in PA imaging.en_US
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en_US
dc.language.isoenen_US
dc.relation.ispartofseriesNano Lettersen_US
dc.rights© 2017 American Chemical Society. This is the author created version of a work that has been peer reviewed and accepted for publication by Nano Letters, American Chemical Society. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1021/acs.nanolett.7b02106].en_US
dc.subjectPolymer nanoparticlesen_US
dc.subjectPhotoacoustic imagingen_US
dc.titleBroadband Absorbing Semiconducting Polymer Nanoparticles for Photoacoustic Imaging in Second Near-Infrared Windowen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doihttp://dx.doi.org/10.1021/acs.nanolett.7b02106
dc.description.versionAccepted version
dc.identifier.rims202091


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