Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/85077
Title: Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases
Authors: Baek, Jong-Suep
Yeo, Eng Wan
Lee, Yin Hao
Tan, Nguan Soon
Loo, Say Chye Joachim
Keywords: NSAIDs
Multi-drug encapsulation
Issue Date: 2017
Source: Baek, J.-S., Yeo, E. W., Lee, Y. H., Tan, N. S., & Loo, S. C. J. (2017). Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases. Drug Design, Development and Therapy, 11, 1707-1717.
Series/Report no.: Drug Design, Development and Therapy
Abstract: The World Health Organization (WHO) has reported that globally 235 million people suffer from chronic and other inflammatory diseases. The short half-lives of nonsteroidal anti-inflammatory drugs (NSAIDs) and their notoriety in causing gastrointestinal discomforts, warrants these drugs to be released in a controlled and sustained manner. Although polymeric particles have been widely used for drug delivery, there are few reports that showcase their ability in encapsulating and sustaining the release of NSAIDs. In this paper, polymeric nanoencapsulating microcapsules loaded with NSAIDs were fabricated using solid/water/oil/water emulsion solvent evaporation method. Two NSAIDs, ibuprofen and naproxen, were first pre-loaded into nanoparticles and then encapsulated into a larger hollow microcapsule that contained the third NSAID, celecoxib. A high encapsulation efficiency (%) of these NSAIDs was achieved and a sustained release (up to 30 days) of these drugs in phosphate-buffered saline was observed. Then, a gastrointestinal drug – cimetidine (CIM) – was co-loaded with the NSAIDs. This floating delivery system exhibited excellent buoyancy (~88% up to 24 h) in simulated gastric fluid. It also allowed a sequential release of the drugs, whereby an immediate release of CIM followed by NSAIDs was observed. Drug release of the NSAIDs observed Fickian diffusion mechanism, whereas CIM observed non-Fickian diffusion. Therefore, this delivery system is a promising platform to control the delivery of NSAIDs to combat inflammatory diseases, thereby protecting against possible gastrointestinal side effects that may arise from the overuse of NSAIDs.
URI: https://hdl.handle.net/10356/85077
http://hdl.handle.net/10220/43653
ISSN: 1177-8881
DOI: http://dx.doi.org/10.2147/DDDT.S133344
Rights: © 2017 Baek et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
metadata.item.grantfulltext: open
metadata.item.fulltext: With Fulltext
Appears in Collections:MSE Journal Articles
SBS Journal Articles
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