dc.contributor.authorXu, Weili
dc.contributor.authorLarbi, Anis
dc.date.accessioned2017-09-12T09:20:15Z
dc.date.available2017-09-12T09:20:15Z
dc.date.issued2017
dc.identifier.citationXu, W., & Larbi, A. (2017). Markers of T Cell Senescence in Humans. International Journal of Molecular Sciences, 18(8), 1742-en_US
dc.identifier.issn1661-6596en_US
dc.identifier.urihttp://hdl.handle.net/10220/43738
dc.description.abstractMany countries are facing the aging of their population, and many more will face a similar obstacle in the near future, which could be a burden to many healthcare systems. Increased susceptibility to infections, cardiovascular and neurodegenerative disease, cancer as well as reduced efficacy of vaccination are important matters for researchers in the field of aging. As older adults show higher prevalence for a variety of diseases, this also implies higher risk of complications, including nosocomial infections, slower recovery and sequels that may reduce the autonomy and overall quality of life of older adults. The age-related effects on the immune system termed as “immunosenescence” can be exemplified by the reported hypo-responsiveness to influenza vaccination of the elderly. T cells, which belong to the adaptive arm of the immune system, have been extensively studied and the knowledge gathered enables a better understanding of how the immune system may be affected after acute/chronic infections and how this matters in the long run. In this review, we will focus on T cells and discuss the surface and molecular markers that are associated with T cell senescence. We will also look at the implications that senescent T cells could have on human health and diseases. Finally, we will discuss the benefits of having these markers for investigators and the future work that is needed to advance the field of T cell senescence markers.en_US
dc.description.sponsorshipASTAR (Agency for Sci., Tech. and Research, S’pore)en_US
dc.format.extent13 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesInternational Journal of Molecular Sciencesen_US
dc.rights© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.subjectHuman agingen_US
dc.subjectImmunosenescenceen_US
dc.titleMarkers of T Cell Senescence in Humansen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.identifier.doihttp://dx.doi.org/10.3390/ijms18081742
dc.description.versionPublished versionen_US


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