Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/85591
Title: Functional properties, topological organization and sexual dimorphism of claustrum neurons projecting to anterior cingulate cortex
Authors: Chia, Zach
Silberberg, Gilad
Augustine, George James
Keywords: Anterior cingulate cortex
Claustrum
Issue Date: 2017
Source: Chia, Z., Silberberg, G., & Augustine, G. J. (2017). Functional properties, topological organization and sexual dimorphism of claustrum neurons projecting to anterior cingulate cortex. Claustrum, 2(1), 1357412-.
Series/Report no.: Claustrum
Abstract: Objective: To define the physiological properties of neurons projecting from the claustrum to the anterior cingulate cortex (ACC). Design: To identify the claustrum in live slices, we used a transgenic mouse line that expresses yellow fluorescent protein (YFP)-tagged Volvox channelrhodopsin-1 at high levels within the claustrum. Claustrum cells projecting to the ACC were identified by retrograde labelling. Whole-cell patch-clamp recordings from labelled claustrum neurons were used to characterize the intrinsic electrical properties of these neurons. Cells were classified according to their intrinsic electrical properties, based on a previous classification scheme. Results: Labelled neurons were found in the claustrum but not the insular cortex. Four types of ACC-projecting neurons were identified based on action potential adaptation and waveform: strongly adapting (SA) cell types 2, 3 and 4, and moderately adapting (MA) cell type 2. Labelled cells were predominantly SA4 in the anterior (44%) and posterior (63%) claustrum, while MA2 predominated (77%) in the central claustrum. The male anterior claustrum showed a bias toward SA3 cells (53%) while the female anterior claustrum showed a bias toward SA3 cells (76%). Conclusions: There is ipsilateral dominance for ACC-projecting claustrum neurons, with the intrinsic properties of these neurons varying along the anterior–posterior axis. Sexual dimorphism was observed in ACC-projecting claustrum cells. Our results are consistent with the hypothesis that the claustrum serves as a link between the insular cortex and the ACC.
URI: https://hdl.handle.net/10356/85591
http://hdl.handle.net/10220/43764
DOI: 10.1080/20023294.2017.1357412
Rights: © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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