dc.contributor.authorUpputuri, Paul Kumar
dc.contributor.authorPeriyasamy, Vijitha
dc.contributor.authorKalva, Sandeep Kumar
dc.contributor.authorPramanik, Manojit
dc.identifier.citationUpputuri, P. K., Periyasamy, V., Kalva, S. K., & Pramanik, M. (2017). A High-performance Compact Photoacoustic Tomography System for In Vivo Small-animal Brain Imaging. Journal of Visualized Experiments, (124), e55811-.en_US
dc.description.abstractIn vivo small-animal imaging has an important role to play in preclinical studies. Photoacoustic tomography (PAT) is an emerging hybrid imaging modality that shows great potential for both preclinical and clinical applications. Conventional optical parametric oscillator-based PAT (OPO-PAT) systems are bulky and expensive and cannot provide high-speed imaging. Recently, pulsed-laser diodes (PLDs) have been successfully demonstrated as an alternative excitation source for PAT. Pulsed-laser diode PAT (PLD-PAT) has been successfully demonstrated for high-speed imaging on photoacoustic phantoms and biological tissues. This work provides a visualized experimental protocol for in vivo brain imaging using PLD-PAT. The protocol includes the compact PLD-PAT system configuration and its description, animal preparation for brain imaging, and a typical experimental procedure for 2D cross-sectional rat brain imaging. The PLD-PAT system is compact and cost-effective and can provide high-speed, high-quality imaging. Brain images collected in vivo at various scan speeds are presented.en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en_US
dc.description.sponsorshipMOH (Min. of Health, S’pore)en_US
dc.format.extent6 p.en_US
dc.relation.ispartofseriesJournal of Visualized Experimentsen_US
dc.rights© 2017 Journal of Visualized Experiments. This paper was published in Journal of Visualized Experiments and is made available as an electronic reprint (preprint) with permission of Journal of Visualized Experiments. The published version is available at: [http://dx.doi.org/10.3791/55811]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.en_US
dc.subjectPhotoacoustic tomographyen_US
dc.subjectBiomedical imagingen_US
dc.titleA High-performance compact photoacoustic tomography system for in vivo small-animal brain imagingen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.description.versionPublished versionen_US

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