Magnetic Janus Particles Synthesized by Droplet Micro-magnetofluidic Techniques for Protein Detection
Varma, Vijaykumar Babulalji
Ramanujan, Raju Vijayaraghavan
Date of Issue2017
School of Materials Science and Engineering
Singapore Institute of Manufacturing Technology
Magnetic droplets on a microfluidic platform can acts as micro-robots, providing wireless, remote, and programmable control. This field of droplet micro-magnetofluidics (DMMF) is useful for droplet merging, mixing and synthesis of Janus structures. Specifically, magnetic Janus particles (MJP) are useful for protein and DNA detection as well as magnetically controlled bioprinting. However, synthesis of MJP with control of the functional phases is a challenge. Hence, we developed a high flow rate, surfactant-free, wash-less method to synthesize MJP by integration of DMMF with hybrid magnetic fields. The effect of flow rate, flow rate ratio, and the hybrid magnetic field on the magnetic component of the Janus droplets and the MJP was investigated. It was found that the magnetization, particle size, and phase distribution inside MJP could be readily tuned by the flow rates and the magnetic field. The magnetic component in the MJP could be concentrated after mixing at flow rate ratio values less than 7.5 and flow rates less than 3 ml/h. The experimental results and our simulations are in good agreement. The synthesized magnetic-fluorescent Janus particles were used for protein detection, with BSA as a model protein.
Lab on a Chip
© 2017 The Royal Society of Chemistry. This is the author created version of a work that has been peer reviewed and accepted for publication by Lab on a Chip, The Royal Society of Chemistry. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1039/C7LC00830A].