dc.contributor.authorWu, Xingxing
dc.contributor.authorLiu, Bin
dc.contributor.authorZhang, Yuexia
dc.contributor.authorJeret, Martin
dc.contributor.authorWang, Honglin
dc.contributor.authorZheng, Pengcheng
dc.contributor.authorYang, Song
dc.contributor.authorSong, Bao-An
dc.contributor.authorChi, Yonggui Robin
dc.date.accessioned2017-09-22T03:57:17Z
dc.date.available2017-09-22T03:57:17Z
dc.date.issued2016
dc.identifier.citationWu, X., Liu, B., Zhang, Y., Jeret, M., Wang, H., Zheng, P., et al. (2016). Enantioselective Nucleophilic β-Carbon-Atom Amination of Enals: Carbene-Catalyzed Formal [3+2] Reactions. Angewandte Chemie International Edition, 55(40), 12280-12284.en_US
dc.identifier.issn1433-7851en_US
dc.identifier.urihttp://hdl.handle.net/10220/43780
dc.description.abstractAn enantioselective β-carbon amination for enals is disclosed. The nitrogen atom from a protected hydrazine with suitable electronic properties readily behaves as a nucleophile. Addition of the nitrogen nucleophile to a catalytically generated N-heterocyclic-carbene-bound α,β-unsaturated acyl azolium intermediate constructs a new carbon–nitrogen bond asymmetrically. The pyrazolidinone products from our catalytic reactions are common scaffolds in bioactive molecules, and can be easily transformed into useful compounds such as β3-amino-acid derivatives.en_US
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.language.isoenen_US
dc.relation.ispartofseriesAngewandte Chemie International Editionen_US
dc.rights© 2016 Wiley-VCH Verlag GmbH &Co. KGaA, Weinheimen_US
dc.subjectCycloadditionen_US
dc.subjectHeterocyclesen_US
dc.titleEnantioselective Nucleophilic β-Carbon-Atom Amination of Enals: Carbene-Catalyzed Formal [3+2] Reactionsen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doihttp://dx.doi.org/10.1002/anie.201606571


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