dc.contributor.authorMoothanchery, Mohesh
dc.contributor.authorSeeni, Razina Z.
dc.contributor.authorXu, Chenjie
dc.contributor.authorPramanik, Manojit
dc.identifier.citationMoothanchery, M., Seeni, R. Z., Xu, C., & Pramanik, M. (2017). In vivo studies of transdermal nanoparticle delivery with microneedles using photoacoustic microscopy. Biomedical Optics Express, 8(12), 5483-5492.en_US
dc.description.abstractMicroneedle technology allows micron-sized conduits to be formed within the outermost skin layers for both localized and systemic delivery of therapeutics including nanoparticles. Histological methods are often employed for characterization, and unfortunately do not allow for the in vivo visualization of the delivery process. This study presents the utilization of optical resolution-photoacoustic microscopy to characterize the transdermal delivery of nanoparticles using microneedles. Specifically, we observe the in vivo transdermal delivery of gold nanoparticles using microneedles in mice ear and study the penetration, diffusion, and spatial distribution of the nanoparticles in the tissue. The promising results reveal that photoacoustic microscopy can be used as a potential imaging modality for the in vivo characterization of microneedles based drug delivery.en_US
dc.format.extent10 p.en_US
dc.relation.ispartofseriesBiomedical Optics Expressen_US
dc.rights© 2017 Optical Society of America. This is the author created version of a work that has been peer reviewed and accepted for publication by Biomedical Optics Express, Optical Society of America. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [https://doi.org/10.1364/BOE.8.005483].en_US
dc.subjectPhotoacoustic Imagingen_US
dc.titleIn vivo studies of transdermal nanoparticle delivery with microneedle using photoacoustic microscopyen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.description.versionAccepted versionen_US

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