dc.contributor.authorDiez, Juan Antonio
dc.contributor.authore Drigo, Rafael Arrojo
dc.contributor.authorZheng, Xiaofeng
dc.contributor.authorStelmashenko, Olga Victoria
dc.contributor.authorChua, Minni
dc.contributor.authorRodriguez-Diaz, Rayner
dc.contributor.authorFukuda, Masahiro
dc.contributor.authorKöhler, Martin
dc.contributor.authorLeibiger, Ingo
dc.contributor.authorTun, Sai Bo Bo
dc.contributor.authorAli, Yusuf
dc.contributor.authorAugustine, George James
dc.contributor.authorBarathi, Veluchamy A.
dc.contributor.authorBerggren, Per-Olof
dc.date.accessioned2017-11-24T08:15:31Z
dc.date.available2017-11-24T08:15:31Z
dc.date.issued2017
dc.identifier.citationDiez, J. A., e Drigo, R. A., Zheng, X., Stelmashenko, O. V., Chua, M., Rodriguez-Diaz, R., et al. (2017). Pancreatic Islet Blood Flow Dynamics in Primates. Cell Reports, 20(6), 1490-1501.en_US
dc.identifier.issn2211-1247en_US
dc.identifier.urihttp://hdl.handle.net/10220/44084
dc.description.abstractBlood flow regulation in pancreatic islets is critical for function but poorly understood. Here, we establish an in vivo imaging platform in a non-human primate where islets transplanted autologously into the anterior chamber of the eye are monitored non-invasively and longitudinally at single-cell resolution. Engrafted islets were vascularized and innervated and maintained the cytoarchitecture of in situ islets in the pancreas. Blood flow velocity in the engrafted islets was not affected by increasing blood glucose levels and/or the GLP-1R agonist liraglutide. However, islet blood flow was dynamic in nature and fluctuated in various capillaries. This was associated with vasoconstriction events resembling a sphincter-like action, most likely regulated by adrenergic signaling. These observations suggest a mechanism in primate islets that diverts blood flow to cell regions with higher metabolic demand. The described imaging technology applied in non-human primate islets may contribute to a better understanding of human islet pathophysiology.en_US
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en_US
dc.format.extent13 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesCell Reportsen_US
dc.rights© 2017 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.subjectPancreatic Isleten_US
dc.subjectBlood Flowen_US
dc.titlePancreatic Islet Blood Flow Dynamics in Primatesen_US
dc.typeJournal Article
dc.contributor.schoolLee Kong Chian School of Medicineen_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.celrep.2017.07.039
dc.description.versionPublished versionen_US
dc.contributor.organizationNanyang Institute of Structural Biologyen_US


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