dc.contributor.authorMohamed, Gadisti Aisha
dc.contributor.authorCheng, Ruey-Kuang
dc.contributor.authorHo, Joses
dc.contributor.authorKrishnan, Seetha
dc.contributor.authorMohammad, Farhan
dc.contributor.authorClaridge-Chang, Adam
dc.contributor.authorJesuthasan, Suresh
dc.date.accessioned2017-12-20T08:10:26Z
dc.date.available2017-12-20T08:10:26Z
dc.date.issued2017
dc.identifier.citationMohamed, G. A., Cheng, R.-K., Ho, J., Krishnan, S., Mohammad, F., Claridge-Chang, et al. (2017). Optical inhibition of larval zebrafish behaviour with anion channelrhodopsins. BMC Biology, 15(1), 103-.en_US
dc.identifier.issn1741-7007en_US
dc.identifier.urihttp://hdl.handle.net/10220/44172
dc.description.abstractOptical silencing of activity provides a way to test the necessity of neurons in behaviour. Two light-gated anion channels, GtACR1 and GtACR2, have recently been shown to potently inhibit activity in cultured mammalian neurons and in Drosophila. Here, we test the usefulness of these channels in larval zebrafish, using spontaneous coiling behaviour as the assay.en_US
dc.description.sponsorshipASTAR (Agency for Sci., Tech. and Research, S’pore)en_US
dc.format.extent12 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesBMC Biologyen_US
dc.rights© 2017 The Author(s) (BioMed Central). This paper was published in BMC Biology and is made available as an electronic reprint (preprint) with permission of The Author(s) (BioMed Central). The published version is available at: [http://dx.doi.org/10.1186/s12915-017-0430-2]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.en_US
dc.subjectOptogeneticsen_US
dc.subjectZebrafishen_US
dc.titleOptical inhibition of larval zebrafish behaviour with anion channelrhodopsinsen_US
dc.typeJournal Article
dc.contributor.schoolLee Kong Chian School of Medicineen_US
dc.identifier.doihttp://dx.doi.org/10.1186/s12915-017-0430-2
dc.description.versionPublished versionen_US


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