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Title: Tissue-like phantoms for quantitative birefringence imaging
Authors: Liu, Xinyu
Beaudette, Kathy
Wang, Xianghong
Liu, Linbo
Bouma, Brett E.
Villiger, Martin
Keywords: Optical Coherence Tomography
Polarimetric Imaging
Issue Date: 2017
Source: Liu, X., Beaudette, K., Wang, X., Liu, L., Bouma, B. E., & Villiger, M. (2017). Tissue-like phantoms for quantitative birefringence imaging. Biomedical Optics Express, 8(10), 4454-4465.
Series/Report no.: Biomedical Optics Express
Abstract: Birefringence imaging, including polarization sensitive optical coherence tomography (PS-OCT), can provide valuable insight into the microscopic structure and organization of many biological tissues. In this paper, we report on a method to fabricate tissue-like birefringence phantoms for such imaging modalities. We utilize the photo-elastic effect, wherein birefringence is induced by stretching a polymer sample after heating it above its glass-transition temperature. The cooled samples stably exhibit homogeneous birefringence, and were assembled into phantoms containing multiple well-defined regions of distinct birefringence. We present planar slab phantoms for microscopy applications and cylindrical phantoms for catheter-based imaging and demonstrate quantitative analysis of the birefringence within individual regions of interest. Birefringence phantoms enable testing, validating, calibrating, and improving PS-OCT acquisition systems and reconstruction strategies.
DOI: 10.1364/BOE.8.004454
Rights: ©2017 Optical Society of America (OSA). This paper was published in Biomedical Optics Express and is made available as an electronic reprint (preprint) with permission of Optical Society of America (OSA). The published version is available at: []. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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