dc.contributor.authorXu, Wengang
dc.contributor.authorYoshikai, Naohiko
dc.date.accessioned2018-01-08T06:40:31Z
dc.date.available2018-01-08T06:40:31Z
dc.date.issued2017
dc.identifier.citationXu, W., & Yoshikai, N. (2017). Pivalophenone imine as a benzonitrile surrogate for directed C–H bond functionalization. Chemical Science, 8(8), 5299-5304.en_US
dc.identifier.issn2041-6520en_US
dc.identifier.urihttp://hdl.handle.net/10220/44261
dc.description.abstractPivalophenone N–H imine has been found to serve as a prominent substrate for directed C–H alkylation and arylation reactions with alkyl bromides and aryl chlorides, respectively, under cobalt–N-heterocyclic carbene (NHC) catalysis. Unlike the case of the parent pivalophenone imine, the increased steric bulk of the resulting ortho-substituted pivalophenone imines allows them to undergo clean imine-to-nitrile conversion under peroxide photolysis or aerobic copper catalysis conditions. Overall, these two-step transformations offer convenient synthetic methods for ortho-functionalized benzonitriles.en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.format.extent6 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesChemical Scienceen_US
dc.rights© 2017 The Author(s) (published by Royal Society of Chemistry). This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.en_US
dc.subjectC–H Bond Functionalizationen_US
dc.subjectArylation Reactionsen_US
dc.titlePivalophenone imine as a benzonitrile surrogate for directed C–H bond functionalizationen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doihttp://dx.doi.org/10.1039/C7SC01732D
dc.description.versionPublished versionen_US


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