Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/87032
Title: Macrophage–Bacteria Interactions—A Lipid-Centric Relationship
Authors: Teng, Ooiean
Ang, Candice Ke En
Guan, Xue Li
Keywords: Lipids
Metabolism
Issue Date: 2017
Source: Teng, O., Ang, C. K. E., & Guan, X. L. (2017). Macrophage–Bacteria Interactions—A Lipid-Centric Relationship. Frontiers in Immunology, 8, 1836-.
Series/Report no.: Frontiers in Immunology
Abstract: Macrophages are professional phagocytes at the front line of immune defenses against foreign bodies and microbial pathogens. Various bacteria, which are responsible for deadly diseases including tuberculosis and salmonellosis, are capable of hijacking this important immune cell type and thrive intracellularly, either in the cytoplasm or in specialized vacuoles. Tight regulation of cellular metabolism is critical in shaping the macrophage polarization states and immune functions. Lipids, besides being the bulk component of biological membranes, serve as energy sources as well as signaling molecules during infection and inflammation. With the advent of systems-scale analyses of genes, transcripts, proteins, and metabolites, in combination with classical biology, it is increasingly evident that macrophages undergo extensive lipid remodeling during activation and infection. Each bacterium species has evolved its own tactics to manipulate host metabolism toward its own advantage. Furthermore, modulation of host lipid metabolism affects disease susceptibility and outcome of infections, highlighting the critical roles of lipids in infectious diseases. Here, we will review the emerging roles of lipids in the complex host–pathogen relationship and discuss recent methodologies employed to probe these versatile metabolites during the infection process. An improved understanding of the lipid-centric nature of infections can lead to the identification of the Achilles’ heel of the pathogens and host-directed targets for therapeutic interventions. Currently, lipid-moderating drugs are clinically available for a range of non-communicable diseases, which we anticipate can potentially be tapped into for various infections.
URI: https://hdl.handle.net/10356/87032
http://hdl.handle.net/10220/44282
DOI: http://dx.doi.org/10.3389/fimmu.2017.01836
Rights: © 2017 Teng, Ang and Guan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
metadata.item.grantfulltext: open
metadata.item.fulltext: With Fulltext
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