Pulsed laser diode photoacoustic tomography (PLD-PAT) system for fast in vivo imaging of small animal brain
Upputuri, Paul Kumar
Kalva, Sandeep Kumar
Date of Issue2017
Proceedings of SPIE - Photons Plus Ultrasound: Imaging and Sensing 2017
School of Chemical and Biomedical Engineering
In recent years, high-repetition rate pulsed laser diode (PLD) was used as an alternative to the Nd:YAG lasers for photoacoustic tomography (PAT). The use of PLD makes the overall PAT system, a low-cost, portable, and high frame rate imaging tool for preclinical applications. In this work, we will present a portable in vivo pulsed laser diode based photoacoustic tomography (PLD–PAT) system. The PLD is integrated inside a circular scanning geometry. The PLD can provide near-infrared (∼803 nm) pulses with pulse duration ∼136 ns, and pulse energy ∼1.4 mJ / pulse at 7 kHz repetition rate. The system will be demonstrated for in vivo fast imaging of small animal brain. To enhance the contrast of brain imaging, experiments will be carried out using contrast agents which have strong absorption around laser excitation wavelength. This low-cost, portable small animal brain imaging system could be very useful for brain tumor imaging and therapy.
Pulsed Laser Diode
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE). This paper was published in Proceedings of SPIE - Photons Plus Ultrasound: Imaging and Sensing 2017 and is made available as an electronic reprint (preprint) with permission of Society of Photo-Optical Instrumentation Engineers (SPIE). The published version is available at: [http://dx.doi.org/10.1117/12.2250481]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.