dc.contributor.authorSivasubramanian, Kathyayini
dc.contributor.authorPeriyasamy, Vijitha
dc.contributor.authorPramanik, Manojit
dc.date.accessioned2018-01-19T02:24:22Z
dc.date.available2018-01-19T02:24:22Z
dc.date.copyright2018
dc.date.issued2017
dc.identifier.citationSivasubramanian, K., Periyasamy, V., & Pramanik, M. (2018). Non-invasive sentinel lymph node mapping and needle guidance using clinical handheld photoacoustic imaging system in small animal. Journal of Biophotonics, 11(1), e201700061-.en_US
dc.identifier.issn1864-063Xen_US
dc.identifier.urihttp://hdl.handle.net/10220/44326
dc.description.abstractTranslating photoacoustic imaging (PAI) into clinical setup is a challenge. Handheld clinical real-time PAI systems are not common. In this work, we report an integrated photoacoustic (PA) and clinical ultrasound imaging system by combining light delivery with the ultrasound probe for sentinel lymph node imaging and needle guidance in small animal. The open access clinical ultrasound platform allows seamless integration of PAI resulting in the development of handheld real-time PAI probe. Both methylene blue and indocyanine green were used for mapping the sentinel lymph node using 675 and 690 nm wavelength illuminations, respectively. Additionally, needle guidance with combined ultrasound and PAI was demonstrated using this imaging system. Up to 1.5 cm imaging depth was observed with a 10 Hz laser at an imaging frame rate of 5 frames per second, which is sufficient for future translation into human sentinel lymph node imaging and needle guidance for fine needle aspiration biopsy.en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.format.extent27 p.
dc.language.isoenen_US
dc.relation.ispartofseriesJournal of Biophotonicsen_US
dc.rights© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of Biophotonics, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1002/jbio.201700061].en_US
dc.subjectClinical Photoacoustic Systemen_US
dc.subjectFine Needle Aspiration Biopsyen_US
dc.titleNon-invasive sentinel lymph node mapping and needle guidance using clinical handheld photoacoustic imaging system in small animalen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.identifier.doihttp://dx.doi.org/10.1002/jbio.201700061
dc.description.versionAccepted version
dc.identifier.rims202089


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