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Title: Oxytocin receptor gene polymorphisms (rs53576) and early paternal care sensitize males to distressing female vocalizations
Authors: Truzzi, Anna
Poquérusse, Jessie
Setoh, Peipei
Shinohara, Kazuyuki
Bornstein, Marc H.
Esposito, Gianluca
Keywords: Gene–environment
Oxytocin Receptor Gene
Issue Date: 2018
Source: Truzzi, A., Poquérusse, J., Setoh, P., Shinohara, K., Bornstein, M. H., & Esposito, G. (2018). Oxytocin receptor gene polymorphisms (rs53576) and early paternal care sensitize males to distressing female vocalizations. Developmental Psychobiology, in press.
Series/Report no.: Developmental Psychobiology
Abstract: The oxytocinergic system is highly involved in social bonding and early caregiver–infant interactions. Here, we hypothesize that oxytocin receptor (OXTR) gene genotype and parental bonding history interact in influencing social development. To address this question, we assessed adult males’ arousal (heart rate changes) in response to different distress vocalizations (human female, human infant and bonobo). Region rs53576 of the OXTR gene was genotyped from buccal mucosa cell samples, and a self-report Parental Bonding Instrument was used (which provide information about parental care or parental overprotection). A significant gene–environment interaction between OXTR genotype and parenting style was found to influence participants’ social responsivity to female cry vocalizations. Specifically, a history of appropriate paternal care in participants accentuated the heightened social sensitivity determined by G/G homozygosity, while higher versus lower paternal overprotection lead to distinct levels of physiological arousal particularly in A carriers individuals. These results add to our understanding of the dynamic interplay between genetic susceptibility and early environmental experience in shaping the development of appropriate social sensitivity in males.
ISSN: 0012-1630
DOI: 10.1002/dev.21606
Rights: © 2018 Wiley Periodicals, Inc. This is the author created version of a work that has been peer reviewed and accepted for publication by Developmental Psychobiology, Wiley Periodicals, Inc. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:HSS Journal Articles

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