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Title: Simulation of non-linear acoustic field and thermal pattern of phased-array high-intensity focused ultrasound (HIFU)
Authors: Wang, Mingjun
Zhou, Yufeng
Keywords: High Intensity Focused Ultrasound (HIFU)
Angular Spectrum Approach
Issue Date: 2016
Source: Wang, M., & Zhou, Y. (2016). Simulation of non-linear acoustic field and thermal pattern of phased-array high-intensity focused ultrasound (HIFU). International Journal of Hyperthermia, 32(5), 569-582.
Series/Report no.: International Journal of Hyperthermia
Abstract: Purpose: HIFU becomes an effective and non-invasive modality of solid tumour/cancer ablation. Simulation of the non-linear acoustic wave propagation using a phased-array transducer in multiple layered media using different focusing strategies and the consequent lesion formation are essential in HIFU planning in order to enhance the efficacy and efficiency of treatment. Materials and methods: An angular spectrum approach with marching fractional steps was applied in the wave propagation from phased-array HIFU transducer, and diffraction, attenuation, and non-linearity effects were accounted for by a second-order operator splitting scheme. The simulated distributions of the first three harmonics along and transverse to the transducer axis were compared to the hydrophone measurements. The bioheat equation was used to simulate the subsequent temperature elevation using the deposited acoustic energy, and lesion formation was determined by the thermal dose. Results: Better agreement was found between the measured harmonics distribution and simulation using the proposed algorithm than the Khokhlov–Zabozotskaya–Kuznetsov equation. Variable focusing of the phased-array transducer (geometric focusing, transverse shifting and the generation of multiple foci) can be simulated successfully. The shifting and splitting of focus was found to result in significantly less temperature elevation at the focus and the subsequently, the smaller lesion size, but the larger grating lobe grating lobe in the pre-focal region. Conclusions: The proposed algorithm could simulate the non-linear wave propagation from the source with arbitrary shape and distribution of excitation through multiple tissue layers in high computation accuracy. The performance of phased-array HIFU can be optimised in the treatment planning.
ISSN: 0265-6736
Rights: © 2016 Informa UK Limited. This is the author created version of a work that has been peer reviewed and accepted for publication by International Journal of Hyperthermia, Informa UK Limited. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MAE Journal Articles

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