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Title: Cytochalasin B-induced membrane vesicles convey angiogenic activity of parental cells
Authors: Gomzikova, Marina O.
Zhuravleva, Margarita N.
Miftakhova, Regina R.
Arkhipova, Svetlana S.
Evtugin, Vladimir G.
Khaiboullina, Svetlana F.
Kiyasov, Andrey P.
Persson, Jenny L.
Mongan, Nigel P.
Rizvanov, Albert A.
Pestell, Richard George
Keywords: Membrane Vesicles
Extracellular Vesicles
Issue Date: 2017
Source: Gomzikova, M. O., Zhuravleva, M. N., Miftakhova, R. R., Arkhipova, S. S., Evtugin, V. G., Khaiboullina, S. F., et al. (2017). Cytochalasin B-induced membrane vesicles convey angiogenic activity of parental cells. Oncotarget, 8(41), 70496-70507.
Series/Report no.: Oncotarget
Abstract: Naturally occurring extracellular vesicles (EVs) play essential roles in intracellular communication and delivery of bioactive molecules. Therefore it has been suggested that EVs could be used for delivery of therapeutics. However, to date the therapeutic application of EVs has been limited by number of factors, including limited yield and full understanding of their biological activities. To address these issues, we analyzed the morphology, molecular composition, fusion capacity and biological activity of Cytochalasin B-induced membrane vesicles (CIMVs). The size of these vesicles was comparable to that of naturally occurring EVs. In addition, we have shown that CIMVs from human SH-SY5Y cells contain elevated levels of VEGF as compared to the parental cells, and stimulate angiogenesis in vitro and in vivo.
Rights: © 2017 The Author(s) (published by Impact Journals). This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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