Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/87428
Title: Prior exposure to inhaled allergen enhances anti-viral immunity and T cell priming by dendritic cells
Authors: Lee, Debbie C. P.
Tay, Neil Q.
Thian, Marini
Prabhu, Nayana
Furuhashi, Kazuki
Kemeny, David M.
Keywords: Asthma
Allergen
Issue Date: 2018
Source: Lee, D. C. P., Tay, N. Q., Thian, M., Prabhu, N., Furuhashi, K., & Kemeny, D. M. (2018). Prior exposure to inhaled allergen enhances anti-viral immunity and T cell priming by dendritic cells. PLOS ONE, 13(1), e0190063-.
Series/Report no.: PLOS ONE
Abstract: Influenza and asthma are two of the major public health concerns in the world today. During the 2009 influenza pandemic asthma was found to be the commonest comorbid illness of patients admitted to hospital. Unexpectedly, it was also observed that asthmatic patients admitted to hospital with influenza infection were less likely to die or require admission to intensive care compared with non-asthmatics. Using an in vivo model of asthma and influenza infection we demonstrate that prior exposure to Blomia tropicalis extract (BTE) leads to an altered immune response to influenza infection, comprised of less severe weight loss and faster recovery following infection. This protection was associated with significant increases in T cell numbers in the lungs of BTE sensitised and infected mice, as well as increased IFN-γ production from these cells. In addition, elevated numbers of CD11b+ dendritic cells (DCs) were found in the lung draining lymph nodes following infection of BTE sensitised mice compared to infected PBS treated mice. These CD11b+ DCs appeared to be better at priming CD8 specific T cells both in vivo and ex vivo, a function not normally attributed to CD11b+ DCs. We propose that this alteration in cross-presentation and more efficient T cell priming seen in BTE sensitised mice, led to the earlier increase in T cells in the lungs and subsequently faster clearance of the virus and reduced influenza induced pathology. We believe this data provides a novel mechanism that explains why asthmatic patients may present with less severe disease when infected with influenza.
URI: https://hdl.handle.net/10356/87428
http://hdl.handle.net/10220/44397
DOI: http://dx.doi.org/10.1371/journal.pone.0190063
Rights: © 2018 Lee et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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