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Title: Inter-Species Host Gene Expression Differences in Response to Human and Avian Influenza A Virus Strains
Authors: Taye, Biruhalem
Yeo, Dawn
Lee, Raphael Tze Chuen
Tan, Boon Huan
Sugrue, Richard J.
Maurer-Stroh, Sebastian
Keywords: Influenza A Virus
Issue Date: 2017
Source: Taye, B., Yeo, D., Lee, R. T. C., Tan, B. H., Sugrue, R. J., & Maurer-Stroh, S. (2017). Inter-Species Host Gene Expression Differences in Response to Human and Avian Influenza A Virus Strains. International Journal of Molecular Sciences, 18(11), 2295-.
Series/Report no.: International Journal of Molecular Sciences
Abstract: Low pathogenic avian influenza (LPAI) viruses are a source of sporadic human infections and could also contribute to future pandemic outbreaks but little is known about inter-species differences in the host responses to these viruses. Here, we studied host gene expression signatures of cell lines from three species (human, chicken, and canine) in response to six different viruses (H1N1/WSN, H5N2/F59, H5N2/F118, H5N2/F189, H5N3 and H9N2). Comprehensive microarray probe set re-annotation and ortholog mapping of the host genes was necessary to allow comparison over extended functionally annotated gene sets and orthologous pathways. The annotations are made available to the community for commonly used microarray chips. We observe a strong tendency of the response being cell type- rather than virus-specific. In chicken cells, we found up-regulation of host factors inducing virus infectivity (e.g., oxysterol binding protein like 1A (OSBPL1A) and Rho GTPase activating protein 21 (ARHGAP21)) while reducing apoptosis (e.g., mitochondrial ribosomal protein S27 (MRPS27)) and increasing cell proliferation (e.g., COP9 signalosome subunit 2 (COPS2)). On the other hand, increased antiviral, pro-apoptotic and inflammatory signatures have been identified in human cells while cell cycle and metabolic pathways were down-regulated. This signature describes how low pathogenic avian influenza (LPAI) viruses are being tolerated and shed from chicken but potentially causing cellular disruption in mammalian cells.
ISSN: 1661-6596
DOI: 10.3390/ijms18112295
Rights: © 2017 by The Author(s). Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
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