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https://hdl.handle.net/10356/87345
Title: | Estrogen reprograms the activity of neutrophils to foster protumoral microenvironment during mammary involution | Authors: | Chung, Hwa Hwa Or, Yu Zuan Shrestha, Smeeta Loh, Jia Tong Lim, Chew Leng Ong, Zoe Woo, Amanda Rui En Su, I-hsin Lin, Valerie Chun Ling |
Keywords: | Estrogen Mammary Involution |
Issue Date: | 2017 | Source: | Chung, H. H., Or, Y. Z., Shrestha, S., Loh, J. T., Lim, C. L., Ong, Z., et al. (2017). Estrogen reprograms the activity of neutrophils to foster protumoral microenvironment during mammary involution. Scientific Reports, 7, 46485-. | Series/Report no.: | Scientific Reports | Abstract: | Epidemiological studies have indicated increased risk for breast cancer within 10 years of childbirth. Acute inflammation during mammary involution has been suggested to promote this parity-associated breast cancer. We report here that estrogen exacerbates mammary inflammation during involution. Microarray analysis shows that estrogen induces an extensive proinflammatory gene signature in the involuting mammary tissue. This is associated with estrogen-induced neutrophil infiltration. Furthermore, estrogen induces the expression of protumoral cytokines/chemokines, COX-2 and tissue-remodeling enzymes in isolated mammary neutrophils and systemic neutrophil depletion abolished estrogen-induced expression of these genes in mammary tissue. More interestingly, neutrophil depletion diminished estrogen-induced growth of ERα-negative mammary tumor 4T1 in Balb/c mice. These findings highlight a novel aspect of estrogen action that reprograms the activity of neutrophils to create a pro-tumoral microenvironment during mammary involution. This effect on the microenvironment would conceivably aggravate its known neoplastic effect on mammary epithelial cells. | URI: | https://hdl.handle.net/10356/87345 http://hdl.handle.net/10220/44423 |
ISSN: | 2045-2322 | DOI: | 10.1038/srep46485 | Schools: | School of Biological Sciences | Rights: | © 2017 The Author(s) (Nature Publishing Group). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | SBS Journal Articles |
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Estrogen reprograms the activity of neutrophils to foster protumoral microenvironment during mammary involution.pdf | 1.73 MB | Adobe PDF | View/Open |
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