dc.contributor.authorPellefigues, Christophe
dc.contributor.authorTang, Shiau-Choot
dc.contributor.authorSchmidt, Alfonso
dc.contributor.authorWhite, Ruby F.
dc.contributor.authorLamiable, Olivier
dc.contributor.authorConnor, Lisa M.
dc.contributor.authorRuedl, Christiane
dc.contributor.authorDobrucki, Jurek
dc.contributor.authorLe Gros, Graham
dc.contributor.authorRonchese, Franca
dc.identifier.citationPellefigues, C., Tang, S.-C., Schmidt, A., White, R. F., Lamiable, O., Connor, L. M., et al. (2017). Toll-Like Receptor 4, but Not Neutrophil Extracellular Traps, Promote IFN Type I Expression to Enhance Th2 Responses to Nippostrongylus brasiliensis. Frontiers in Immunology, 8, 1575-.en_US
dc.description.abstractThe induction of Th2 responses is thought to be multifactorial, and emerge from specific pathways distinct from those associated with antagonistic antibacterial or antiviral Th1 responses. Here, we show that the recognition of non-viable Nippostrongylus brasiliensis (Nb) in the skin induces a strong recruitment of monocytes and neutrophils and the release of neutrophil extracellular traps (NETs). Nb also activates toll-like receptor 4 (TLR4) signaling with expression of Ifnb transcripts in the skin and the development of an IFN type I signature on helminth antigen-bearing dendritic cells in draining lymph nodes. Co-injection of Nb together with about 10,000 Gram-negative bacteria amplified this TLR4-dependent but NET-independent IFN type I response and enhanced the development of Th2 responses. Thus, a limited activation of antibacterial signaling pathways is able to boost antihelminthic responses, suggesting a role for bacterial sensing in the optimal induction of Th2 immunity.en_US
dc.format.extent14 p.en_US
dc.relation.ispartofseriesFrontiers in Immunologyen_US
dc.rights© 2017 Pellefigues, Tang, Schmidt, White, Lamiable, Connor, Ruedl, Dobrucki, Le Gros and Ronchese. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.subjectNippostrongylus Brasiliensisen_US
dc.titleToll-Like Receptor 4, but Not Neutrophil Extracellular Traps, Promote IFN Type I Expression to Enhance Th2 Responses to Nippostrongylus brasiliensisen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.description.versionPublished versionen_US

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