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|Title:||Microcapillary imaging of lamina cribrosa in porcine eyes using photoacoustic microscopy||Authors:||Moothanchery, Mohesh
Yan, Alvan Tsz Chung
Girard, Michael J. A.
Optic Nerve Head
|Issue Date:||2018||Source:||Moothanchery, M., Chuangsuwanich, T., Yan, A. T. C., Schmetterer, L., Girard, M. J. A., & Pramanik, M. (2018). Proceedings of SPIE - Photons Plus Ultrasound: Imaging and Sensing 2018, 10494, 104945Q-.||Series/Report no.:||Abstract:||In order to understand the pathophysiology of glaucoma, Lamina cribrosa (LC) perfusion needs to be the subject of thorough investigation. It is currently difficult to obtain high resolution images of the embedded microcapillary network of the LC using conventional imaging techniques. In this study, an optical resolution photoacoustic microscopy (OR-PAM) system was used for imaging lamina cribrosa of an ex vivo porcine eye. Extrinsic contrast agent was used to perfuse the eye via its ciliary arteries. The OR-PAM system have a lateral resolution of 4 μm and an axial resolution of 30 μm. The high resolution system could able resolve a perfused LC microcapillary network to show vascular structure within the LC thickness. OR-PAM could be a promising imaging modality to study the LC perfusion and hence could be used to elucidate the hemodynamic aspect of glaucoma.||URI:||https://hdl.handle.net/10356/87994
|DOI:||http://dx.doi.org/10.1117/12.2287825||Rights:||© 2018 Society of Photo-optical Instrumentation Engineers (SPIE). This paper was published in Proceedings of SPIE - Photons Plus Ultrasound: Imaging and Sensing 2018 and is made available as an electronic reprint (preprint) with permission of SPIE. The published version is available at: [http://dx.doi.org/10.1117/12.2287825]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.||metadata.item.grantfulltext:||open||metadata.item.fulltext:||With Fulltext|
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