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Title: Temperature-correlated afterglow of a semiconducting polymer nanococktail for imaging-guided photothermal therapy
Authors: Zhen, Xu
Xie, Chen
Pu, Kanyi
Keywords: Semiconducting Polymer Nanococktail
Issue Date: 2018
Source: Zhen, X., Xie, C., & Pu, K. (2018). Temperature-correlated afterglow of a semiconducting polymer nanococktail for imaging-guided photothermal therapy. Angewandte Chemie International Editio, 57(15), 3938-3942.
Series/Report no.: Angewandte Chemie International Edition
Abstract: Nanoparticles for photothermal therapy: Real‐time temperature monitoring is critical to reduce the nonspecific damage during photothermal therapy (PTT); however, PTT agents that can emit temperature‐related signals are rare and limited to few inorganic nanoparticles. We herein synthesize a semiconducting polymer nanococktail (SPNCT) that can not only convert photo‐energy to heat but also emit temperature‐correlated luminescence after cessation of light excitation. Such an afterglow luminescence of the SPNCT detects tumors more sensitively than fluorescence as a result of the elimination of tissue autofluorescence, while its temperature‐dependent nature allows tumor temperature to be optically monitored under near‐infrared (NIR) laser irradiation. Thus, SPNCT represents the first organic optical nanosystem that enables optical‐imaging guided PTT without real‐time light excitation.
ISSN: 1433-7851
DOI: 10.1002/anie.201712550
Rights: © 2018 Wiley-VCH Verlag GmbH &Co. KGaA, Weinheim. This is the author created version of a work that has been peer reviewed and accepted for publication by Angewandte Chemie International Edition, Wiley-VCH Verlag GmbH &Co. KGaA, Weinheim. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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