dc.contributor.authorZhen, Xu
dc.contributor.authorZhang, Jianjian
dc.contributor.authorHuang, Jiaguo
dc.contributor.authorXie, Chen
dc.contributor.authorMiao, Qingqing
dc.contributor.authorPu, Kanyi
dc.date.accessioned2018-04-26T05:32:23Z
dc.date.available2018-04-26T05:32:23Z
dc.date.copyright2018
dc.date.issued2018
dc.identifier.citationZhen, X., Zhang, J., Huang, J., Xie, C., Miao, Q., & Pu, K. (2018). Macrotheranostic Probe with Disease-activated Near-infrared Fluorescence, Photoacoustic and Photothermal Signals for Imaging-guided Therapy. Angewandte Chemie International Edition, in press.en_US
dc.identifier.issn1433-7851en_US
dc.identifier.urihttp://hdl.handle.net/10220/44726
dc.description.abstractTheranostics provides opportunities for precision cancer therapy. However, theranostic systems that simultaneously turn on their diagnostic signal and pharmacological action only in respond to targeted biomarker have been less exploited. We herein report the synthesis of a smart macrotheranostic probe that specifically turns on near‐infrared fluorescence, photoacoustic and photothermal signals in the presence of cancer‐overexpressed enzyme for imaging‐guided cancer therapy. Supervisor to the small‐molecule counterpart probe, the macrotheranostic probe has an ideal biodistribution and renal clearance, permitting passive targeting of tumor, in‐situ enzymatic activation of multimodal signals, and effective photothermal therapy. Our study thus provides a macromolecular approach towards activatable multimodal phototheranostics.en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.format.extent5 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesAngewandte Chemie International Editionen_US
dc.rights© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the author created version of a work that has been peer reviewed and accepted for publication by Angewandte Chemie International Edition, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [https://doi.org/10.1002/anie.201803321].en_US
dc.subjectActivatable Macrotheranostic Probeen_US
dc.subjectβ-Galactosidaseen_US
dc.titleMacrotheranostic Probe with Disease-activated Near-infrared Fluorescence, Photoacoustic and Photothermal Signals for Imaging-guided Therapyen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.identifier.doihttps://doi.org/10.1002/anie.201803321
dc.description.versionAccepted versionen_US
dc.identifier.rims206475


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