Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/88819
Title: Semiconducting Polymer Nanoenzymes with Photothermic Activity for Enhanced Cancer Therapy
Authors: Li, Jingchao
Xie, Chen
Huang, Jiaguo
Jiang, Yuyan
Miao, Qingqing
Pu, Kanyi
Keywords: Polymer Nanoparticles
Photothermal Therapy
Issue Date: 2018
Source: Li, J., Xie, C., Huang, J., Jiang, Y., Miao, Q., & Pu, K. (2018). Semiconducting Polymer Nanoenzymes with Photothermic Activity for Enhanced Cancer Therapy. Angewandte Chemie International Edition, 57(15), 3995-3998.
Series/Report no.: Angewandte Chemie International Edition
Abstract: Regulation of enzyme activity is fundamentally challenging but practically meaningful for biology and medicine. However, noninvasive remote control of enzyme activity in living systems has been rarely demonstrated and exploited for therapy. Herein, we synthesize a semiconducting polymer nanoenzyme with photothermic activity for enhanced cancer therapy. Upon near‐infrared (NIR) light irradiation, the activity of the nanoenzyme can be enhanced by 3.5‐fold to efficiently digest collagen in the tumor extracellular matrix (ECM), leading to enhanced nanoparticle accumulation in tumors and consequently improved photothermal therapy (PTT). This study thus provides a promising strategy to remotely regulate enzyme activity for cancer therapy.
URI: https://hdl.handle.net/10356/88819
http://hdl.handle.net/10220/44769
ISSN: 1433-7851
DOI: https://dx.doi.org/10.1002/anie.201800511
Rights: © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the author created version of a work that has been peer reviewed and accepted for publication by Angewandte Chemie International Edition, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [https://dx.doi.org/10.1002/anie.201800511].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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