Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria
Schmid, Christoph D.
Guan, Xue Li
Date of Issue2018
Lee Kong Chian School of Medicine (LKCMedicine)
Combinatorial chemotherapy is necessary for the treatment of malaria. However, finding a suitable partner drug for a new candidate is challenging. Here we develop an algorithm that identifies all of the gene pairs of Plasmodium falciparum that possess orthologues in yeast that have a synthetic lethal interaction but are absent in humans. This suggests new options for drug combinations, particularly for inhibitors of targets such as P. falciparum calcineurin, cation ATPase 4, or phosphatidylinositol 4-kinase.
Antimicrobial Agents and Chemotherapy
© 2018 Subramaniam et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.