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Title: Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria
Authors: Guan, Xue Li
Subramaniam, Suvitha
Schmid, Christoph D.
Mäser, Pascal
Keywords: Antimalarials
Combinatorial Chemotherapy
Issue Date: 2018
Source: Subramaniam, S., Schmid, C. D., Guan, X. L., & Mäser, P. (2018). Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria. Antimicrobial Agents and Chemotherapy, 62(4), e01533-17-.
Series/Report no.: Antimicrobial Agents and Chemotherapy
Abstract: Combinatorial chemotherapy is necessary for the treatment of malaria. However, finding a suitable partner drug for a new candidate is challenging. Here we develop an algorithm that identifies all of the gene pairs of Plasmodium falciparum that possess orthologues in yeast that have a synthetic lethal interaction but are absent in humans. This suggests new options for drug combinations, particularly for inhibitors of targets such as P. falciparum calcineurin, cation ATPase 4, or phosphatidylinositol 4-kinase.
ISSN: 0066-4804
DOI: 10.1128/AAC.01533-17
Rights: © 2018 Subramaniam et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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