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|Title:||Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria||Authors:||Guan, Xue Li
Schmid, Christoph D.
|Issue Date:||2018||Source:||Subramaniam, S., Schmid, C. D., Guan, X. L., & Mäser, P. (2018). Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria. Antimicrobial Agents and Chemotherapy, 62(4), e01533-17-.||Series/Report no.:||Antimicrobial Agents and Chemotherapy||Abstract:||Combinatorial chemotherapy is necessary for the treatment of malaria. However, finding a suitable partner drug for a new candidate is challenging. Here we develop an algorithm that identifies all of the gene pairs of Plasmodium falciparum that possess orthologues in yeast that have a synthetic lethal interaction but are absent in humans. This suggests new options for drug combinations, particularly for inhibitors of targets such as P. falciparum calcineurin, cation ATPase 4, or phosphatidylinositol 4-kinase.||URI:||https://hdl.handle.net/10356/107554
|ISSN:||0066-4804||DOI:||10.1128/AAC.01533-17||Rights:||© 2018 Subramaniam et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||LKCMedicine Journal Articles|
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