A general method for asymmetric arylation and vinylation of silyl ketene acetals
Zhou, Jianrong (Steve)
Date of Issue2014
School of Physical and Mathematical Sciences
A new biarylmonophosphine was developed for highly asymmetric arylation and vinylation of silyl enolates of acyclic esters with good generality. The new stereocenters α to the ester groups were formed in high enantiomeric excess. The method was applied to the asymmetric synthesis of Profen drugs on a gram scale.
Organic Chemistry Frontiers
© 2014 the Partner Organisations. This is the author created version of a work that has been peer reviewed and accepted for publication by Organic Chemistry Frontiers, the Partner Organisations. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1039/C4QO00027G].