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Title: Palladium‐Catalyzed Direct Cyclopropylation of Heterocycles
Authors: Wu, Xiaojin
Lei, Chuanhu
Yue, Guizhou
Zhou, Jianrong (Steve)
Keywords: Heterocycles
Alkyl Halides
Issue Date: 2015
Source: Wu, X., Lei, C., Yue, G., & Zhou, J. (S.) (2015). Palladium‐Catalyzed Direct Cyclopropylation of Heterocycles. Angewandte Chemie International Edition, 54(33), 9601-9605.
Series/Report no.: Angewandte Chemie International Edition
Abstract: Many 1,3‐azoles and thiophenes are directly cyclopropylated in the presence of a simple palladium catalyst. The relative configuration on the three‐membered rings is retained in the products. Thus, the cyclopropyl–halide bond undergoes concerted oxidative addition to palladium(0) and cyclopropyl radicals are not involved in the productive pathway.
ISSN: 1433-7851
DOI: 10.1002/anie.201504735
Rights: © 2015 Wiley-VCH Verlag GmbH &Co. KGaA, Weinheim. This is the author created version of a work that has been peer reviewed and accepted for publication by Angewandte Chemie International Edition, Wiley-VCH Verlag GmbH &Co. KGaA, Weinheim. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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