dc.contributor.authorQin, Xurong
dc.contributor.authorLee, Marcus Wen Yao
dc.contributor.authorZhou, Steve Jianrong
dc.date.accessioned2018-06-01T03:49:09Z
dc.date.available2018-06-01T03:49:09Z
dc.date.copyright2017
dc.date.issued2017
dc.identifier.citationQin, X., Lee, M. W. Y., & Zhou, S. J. (2017). Nickel‐Catalyzed Asymmetric Reductive Heck Cyclization of Aryl Halides to Afford Indolines. Angewandte Chemie International Edition, 56(41), 12723-12726.en_US
dc.identifier.issn1433-7851en_US
dc.identifier.urihttp://hdl.handle.net/10220/44927
dc.description.abstractA nickel‐catalyzed asymmetric reductive Heck reaction of aryl chlorides has been developed that affords substituted indolines with high enantioselectivity. Manganese powder is used as the terminal reductant with water as a proton source. Mechanistically, it is distinct from the palladium‐catalyzed process in that the nickel–carbon bond is converted into a C−H bond to release the product through protonation instead of hydride donation followed by C−H reductive elimination on Pd.en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.format.extent5 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesAngewandte Chemie International Editionen_US
dc.rights© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the author created version of a work that has been peer reviewed and accepted for publication by Angewandte Chemie International Edition, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1002/anie.201707134].en_US
dc.subjectAsymmetric Catalysisen_US
dc.subjectCyclizationen_US
dc.titleNickel-Catalyzed Asymmetric Reductive Heck Cyclization of Aryl Halides to Afford Indolinesen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doihttp://dx.doi.org/10.1002/anie.201707134
dc.description.versionAccepted versionen_US
dc.identifier.rims207470


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