dc.contributor.authorHe, Lei
dc.contributor.authorMeng, Zhenyu
dc.contributor.authorXie, Yi-qun
dc.contributor.authorChen, Xiang
dc.contributor.authorLi, Tianhu
dc.contributor.authorShao, Fangwei
dc.date.accessioned2018-06-04T03:20:52Z
dc.date.available2018-06-04T03:20:52Z
dc.date.issued2017
dc.identifier.citationHe, L., Meng, Z., Xie, Y.-q., Chen, X., Li, T., & Shao, F. (2017). Aza-bridged bisphenanthrolinyl Pt(ii) complexes : efficient stabilization and topological selectivity on telomeric G-quadruplexes. Journal of Inorganic Biochemistry, 166, 135-140.en_US
dc.identifier.issn0162-0134en_US
dc.identifier.urihttp://hdl.handle.net/10220/44940
dc.description.abstractTwo platinum complexes with an aza-bridged bis(1,10-phenanthrolin-2-yl)amine (bpa) were synthesized. The two phenanthrolines in bpa entered a flat plane prior to binding of nucleic acids, which bestowed on the two Pt complexes a significantly high stabilizing ability on both DNA and RNA G-quadruplexes. Further extending alkyl tail from aromatic coordination core enabled the complexes to distinguish GQ sequence based upon the topological folding structures and enhanced the selectivity of the complex against duplex DNA. This study paved the way to develop Pt complexes as GQ stabilizers for specific folding topology and the applications to disease and/or personalized anticancer medicine/therapy.en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.format.extent30 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesJournal of Inorganic Biochemistryen_US
dc.rights© 2016 Elsevier Inc. This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of Inorganic Biochemistry, Elsevier Inc. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1016/j.jinorgbio.2016.11.011].en_US
dc.subjectPt Complexen_US
dc.subjectG-quadruplexen_US
dc.titleAza-bridged bisphenanthrolinyl Pt(ii) complexes : efficient stabilization and topological selectivity on telomeric G-quadruplexesen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.jinorgbio.2016.11.011
dc.description.versionAccepted versionen_US


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