Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/89605
Title: Defining a critical period for inhibitory circuits within the somatosensory cortex
Authors: Lo, Shun Qiang
Sng, Judy C. G.
Augustine, George J.
Keywords: Barrel Cortex
Neural Circuits
Issue Date: 2017
Source: Lo, S. Q., Sng, J. C. G., & Augustine, G. J. (2017). Defining a critical period for inhibitory circuits within the somatosensory cortex. Scientific Reports, 7(1), 7271-.
Series/Report no.: Scientific Reports
Abstract: Although experience-dependent changes in brain inhibitory circuits are thought to play a key role during the “critical period” of brain development, the nature and timing of these changes are poorly understood. We examined the role of sensory experience in sculpting an inhibitory circuit in the primary somatosensory cortex (S1) of mice by using optogenetics to map the connections between parvalbumin (PV) expressing interneurons and layer 2/3 pyramidal cells. Unilateral whisker deprivation decreased the strength and spatial range of inhibitory input provided to pyramidal neurons by PV interneurons in layers 2/3, 4 and 5. By varying the time when sensory input was removed, we determined that the critical period closes around postnatal day 14. This yields the first precise time course of critical period plasticity for an inhibitory circuit.
URI: https://hdl.handle.net/10356/89605
http://hdl.handle.net/10220/44993
ISSN: 2045-2322
DOI: http://dx.doi.org/10.1038/s41598-017-07400-8
Rights: © 2017 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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