Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/82847
Title: | Dynamic transcriptome changes during adipose tissue energy expenditure reveal critical roles for long noncoding RNA regulators | Authors: | Bai, Zhiqiang Chai, Xiao-ran Yoon, Myeong Jin Kim, Hye-Jin LO, Kinyui Alice Zhang, Zhi-chun Xu, Dan Teh, Diana Chee Siang Walet, Arcinas Camille Esther Xu, Shao-hai Chia, Sook-Yoong Chen, Peng Yang, Hongyuan Ghosh, Sujoy Sun, Lei |
Keywords: | Adipose Tissue Protein RNA Binding |
Issue Date: | 2017 | Source: | Bai, Z., Chai, X.-R., Yoon, M. J., Kim, H.-J., LO, K. A., Zhang, Z.-C., et al. (2017). Dynamic transcriptome changes during adipose tissue energy expenditure reveal critical roles for long noncoding RNA regulators. PLOS Biology, 15(8), e2002176-. | Series/Report no.: | PLOS Biology | Abstract: | Enhancing brown fat activity and promoting white fat browning are attractive therapeutic strategies for treating obesity and associated metabolic disorders. To provide a comprehensive picture of the gene regulatory network in these processes, we conducted a series of transcriptome studies by RNA sequencing (RNA-seq) and quantified the mRNA and long noncoding RNA (lncRNA) changes during white fat browning (chronic cold exposure, beta-adrenergic agonist treatment, and intense exercise) and brown fat activation or inactivation (acute cold exposure or thermoneutrality, respectively). mRNA–lncRNA coexpression networks revealed dynamically regulated lncRNAs to be largely embedded in nutrient and energy metabolism pathways. We identified a brown adipose tissue–enriched lncRNA, lncBATE10, that was governed by the cAMP-cAMP response element-binding protein (Creb) axis and required for a full brown fat differentiation and white fat browning program. Mechanistically, lncBATE10 can decoy Celf1 from Pgc1α, thereby protecting Pgc1α mRNA from repression by Celf1. Together, these studies provide a comprehensive data framework to interrogate the transcriptomic changes accompanying energy homeostasis transition in adipose tissue. | URI: | https://hdl.handle.net/10356/82847 http://hdl.handle.net/10220/45030 |
ISSN: | 1544-9173 | DOI: | 10.1371/journal.pbio.2002176 | Schools: | School of Chemical and Biomedical Engineering | Rights: | © 2017 Bai et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | SCBE Journal Articles |
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Dynamic transcriptome changes during adipose tissue energy expenditure reveal critical roles for long noncoding RNA regulators.pdf | 9.5 MB | Adobe PDF | View/Open |
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