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|Title:||Separation of pathogenic bacteria by chain length||Authors:||Beech, Jason P.
Ho, Bao Dang
Tegenfeldt, Jonas O.
|Keywords:||Deterministic Lateral Displacement
|Issue Date:||2018||Source:||Beech, J. P., Ho, B. D., Garriss, G., Oliveira, V., Henriques-Normark, B.,& Tegenfeldt, J. O. (2018). Separation of pathogenic bacteria by chain length. Analytica Chimica Acta, 1000223-231.||Series/Report no.:||Analytica Chimica Acta||Abstract:||Using Deterministic Lateral Displacement devices optimized for sensitivity to particle length, we separatesubpopulations of bacteria depending on known properties that affect their capability to cau se disease(virulence). For the human bacterial pathogen Streptococcus pneumoniae, bacterial chain length and the presence of a capsule are known virulence factors contributing to its ability to cause severe disease.Separation of cultured pneumococci into subpopulations based on morphological type (single cocci,diplococci and chains) will enable more detailed studies of the role they play in virulence. Moreover, wepresent separation of mixed populations of almost genetically identical encapsulated and non-encapsulated pneumococcal strains in our device.||URI:||https://hdl.handle.net/10356/83190
|ISSN:||0003-2670||DOI:||10.1016/j.aca.2017.11.050||Rights:||© 2017 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||LKCMedicine Journal Articles|
SCELSE Journal Articles
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