Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/86648
Title: Green and rapid access to benzocoumarins via direct benzene construction through base-mediated formal [4+2] reaction and air oxidation
Authors: Mou, Chengli
Zhu, Tingshun
Zheng, Pengcheng
Yang, Song
Song, Bao-An
Chi, Robin Yonggui
Keywords: Air Oxidative Aromatization
Arene Construction
Issue Date: 2016
Source: Mou, C., Zhu, T., Zheng, P., Yang, S., Song, B.-A., & Chi, R. Y. (2016). Green and rapid access to benzocoumarins via direct benzene construction through base-mediated formal [4+2] reaction and air oxidation. Advanced Synthesis & Catalysis, 358(5), 707-712.
Series/Report no.: Advanced Synthesis & Catalysis
Abstract: Benzocoumarin is an important structural motif widely found in natural products and synthetic molecules. Traditional methods for the synthesis of benzocoumarins and their derivatives require multiple steps, typically with an intramolecular ester forming reaction to make the lactone ring as the last step. Another major method involves transition metal‐catalyzed coupling or carbon‐hydrogen bond activation reactions starting with pre‐existing aryl frameworks in the substrates. Here we report a new strategy for the green and rapid access to benzocoumarins and their derivatives. Our method uses readily available unsaturated aldehydes and coumarins as the substrates and air as the green oxidant. The overall reaction proceeds through a formal [4+2] process to construct a new benzene ring and thus to afford benzocoumarins in essentially a single step. No metal catalysts were used; no toxic or expensive reagents were involved. The power of our new approach is further demonstrated in a concise formal total synthesis of cannabinol, a bioactive natural product.
URI: https://hdl.handle.net/10356/86648
http://hdl.handle.net/10220/45180
ISSN: 1615-4150
DOI: http://dx.doi.org/10.1002/adsc.201500771
Rights: © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the author created version of a work that has been peer reviewed and accepted for publication by Advanced Synthesis & Catalysis, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1002/adsc.201500771].
metadata.item.grantfulltext: open
metadata.item.fulltext: With Fulltext
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