Rapid access to bicyclic δ-lactones via carbene-catalyzed activation and cascade reaction of unsaturated carboxylic esters
Chi, Robin Yonggui
Date of Issue2016
School of Physical and Mathematical Sciences
Carboxylic esters are an excellent choice of substrates in organic synthesis. Here we demonstrate that carbene-catalyzed activation of α,β-unsaturated ester can be developed to synthesize sophisticated multi-cyclic molecules in a single step cascade process. The iridoid-type lactone products are obtained with high stereo-selectivities, and can readily undergo further transformations.
Organic Chemistry Frontiers
© 2016 The Partner Organisations. This is the author created version of a work that has been peer reviewed and accepted for publication by Organic Chemistry Frontiers, The Partner Organisations. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1039/C5QO00348B].