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Title: Magnetic nanochain integrated microfluidic biochips
Authors: Xiong, Qirong
Lim, Chun Yee
Ren, Jinghua
Zhou, Jiajing
Pu, Kanyi
Chan-Park, Mary Bee Eng
Mao, Hui
Lam, Yee Cheong
Duan, Hongwei
Keywords: Microfluidic
Magnetic Nanochain
Issue Date: 2018
Source: Xiong, Q., Lim, C. Y., Ren, J., Zhou, J., Pu, K., Chan-Park, M. B., et al. (2018). Magnetic nanochain integrated microfluidic biochips. Nature Communications, 9(1), 1743-.
Series/Report no.: Nature Communications
Abstract: Microfluidic biochips hold great potential for liquid analysis in biomedical research and clinical diagnosis. However, the lack of integrated on-chip liquid mixing, bioseparation and signal transduction presents a major challenge in achieving rapid, ultrasensitive bioanalysis in simple microfluidic configurations. Here we report magnetic nanochain integrated microfluidic chip built upon the synergistic functions of the nanochains as nanoscale stir bars for rapid liquid mixing and as capturing agents for specific bioseparation. The use of magnetic nanochains enables a simple planar design of the microchip consisting of flat channels free of common built-in components, such as liquid mixers and surface-anchored sensing elements. The microfluidic assay, using surface-enhanced Raman scattering nanoprobes for signal transduction, allows for streamlined parallel analysis of multiple specimens with greatly improved assay kinetics and delivers ultrasensitive identification and quantification of a panel of cancer protein biomarkers and bacterial species in 1 μl of body fluids within 8 min.
Rights: © 2018 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
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