dc.contributor.authorHoon, Jing Ling
dc.contributor.authorTan, Mei Hua
dc.contributor.authorKoh, Cheng-Gee
dc.identifier.citationHoon, J. L., Tan, M. H., & Koh, C.-G. (2016). The regulation of cellular responses to mechanical cues by Rho GTPases. Cells, 5(2), 17-.en_US
dc.description.abstractThe Rho GTPases regulate many cellular signaling cascades that modulate cell motility, migration, morphology and cell division. A large body of work has now delineated the biochemical cues and pathways, which stimulate the GTPases and their downstream effectors. However, cells also respond exquisitely to biophysical and mechanical cues such as stiffness and topography of the extracellular matrix that profoundly influence cell migration, proliferation and differentiation. As these cellular responses are mediated by the actin cytoskeleton, an involvement of Rho GTPases in the transduction of such cues is not unexpected. In this review, we discuss an emerging role of Rho GTPase proteins in the regulation of the responses elicited by biophysical and mechanical stimuli.en_US
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.format.extent20 p.en_US
dc.rights© 2016 The Author(s); licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.subjectRho GTPasesen_US
dc.subjectMatrix Stiffnessen_US
dc.titleThe regulation of cellular responses to mechanical cues by Rho GTPasesen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.description.versionPublished versionen_US

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