dc.contributor.authorHe, Ji
dc.contributor.authorChen, Huixin
dc.contributor.authorGuo, Yanjia
dc.contributor.authorWang, Liang
dc.contributor.authorZhu, Lingli
dc.contributor.authorKarahan, Huseyin Enis
dc.contributor.authorChen, Yuan
dc.date.accessioned2018-07-27T07:22:40Z
dc.date.available2018-07-27T07:22:40Z
dc.date.issued2018
dc.identifier.citationHe, J., Chen, H., Guo, Y., Wang, L., Zhu, L., Karahan, H. E., et al. (2018). Polycondensation of a perylene bisimide derivative and L-malic acid as water-soluble conjugates for fluorescent labeling of live mammalian cells. Polymers, 10(5), 559-.en_US
dc.identifier.urihttp://hdl.handle.net/10220/45322
dc.description.abstractBased on simple mixing and polymerization of a hydroxyl-containing derivative of perylene bisimide (PBI) and l-malic acid, here, we demonstrate a new type of dye-polymer conjugate, PBI-poly(α,β-malic acid) (PBI–PMA). Benefiting from the excellent water-solubility of weak polyanionic PMA structure and the high fluorescence of PBI, the PBI-PMA conjugates readily dissolve in water, displaying strong pH-dependent fluorescence with the highest intensity at pH 6. Due to the excellent biocompatibility of PMA, those conjugates showed low cytotoxicity on L929 cells. Using L929 and HeLa cells, we also confirmed that the PBI-PMA-labeled cells display intense fluorescence. Overall, the PBI-PMA conjugate demonstrates high potential as a cell labeling agent with its synthesis ease, good solubility in aqueous medium, low cytotoxicity, and high fluorescence.en_US
dc.format.extent10 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesPolymersen_US
dc.rights© 2018 The Author(s). Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.subjectFacile Synthesisen_US
dc.subjectPerylene Bisimideen_US
dc.titlePolycondensation of a perylene bisimide derivative and L-malic acid as water-soluble conjugates for fluorescent labeling of live mammalian cellsen_US
dc.typeJournal Article
dc.contributor.researchNanyang Environment and Water Research Instituteen_US
dc.contributor.researchSingapore Membrane Technology Centreen_US
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.identifier.doihttp://dx.doi.org/10.3390/polym10050559
dc.description.versionPublished versionen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record