dc.contributor.authorBeveridge, Louise A.
dc.contributor.authorKhan, Faisel
dc.contributor.authorStruthers, Allan D.
dc.contributor.authorArmitage, Jane
dc.contributor.authorBarchetta, Ilaria
dc.contributor.authorBressendorff, Iain
dc.contributor.authorCavallo, Maria Gisella
dc.contributor.authorClarke, Robert
dc.contributor.authorDalan, Rinkoo
dc.contributor.authorDreyer, Gavin
dc.contributor.authorGepner, Adam D.
dc.contributor.authorForouhi, Nita G.
dc.contributor.authorHarris, Ryan A.
dc.contributor.authorHitman, Graham A.
dc.contributor.authorLarsen, Thomas
dc.contributor.authorKhadgawat, Rajesh
dc.contributor.authorMarckmann, Peter
dc.contributor.authorMose, Frank H.
dc.contributor.authorPilz, Stefan
dc.contributor.authorScholze, Alexandra
dc.contributor.authorShargorodsky, Marina
dc.contributor.authorSokol, Seth I.
dc.contributor.authorStricker, Hans
dc.contributor.authorZoccali, Carmine
dc.contributor.authorWitham, Miles D.
dc.identifier.citationBeveridge, L. A., Khan, F., Struthers, A. D., Armitage, J., Barchetta, I., Bressendorff, I., et al. (2018). Effect of vitamin D supplementation on markers of vascular function : a systematic review and individual participant meta‐analysis. Journal of the American Heart Association, 7(11), e008273-.en_US
dc.description.abstractBackground Low 25‐hydroxyvitamin D levels are associated with an increased risk of cardiovascular events, but the effect of vitamin D supplementation on markers of vascular function associated with major adverse cardiovascular events is unclear. Methods and Results We conducted a systematic review and individual participant meta‐analysis to examine the effect of vitamin D supplementation on flow‐mediated dilatation of the brachial artery, pulse wave velocity, augmentation index, central blood pressure, microvascular function, and reactive hyperemia index. MEDLINE, CINAHL, EMBASE, Cochrane Central Register of Controlled Trials, and http://www.ClinicalTrials.gov were searched until the end of 2016 without language restrictions. Placebo‐controlled randomized trials of at least 4 weeks duration were included. Individual participant data were sought from investigators on included trials. Trial‐level meta‐analysis was performed using random‐effects models; individual participant meta‐analyses used a 2‐stage analytic strategy, examining effects in prespecified subgroups. 31 trials (2751 participants) were included; 29 trials (2641 participants) contributed data to trial‐level meta‐analysis, and 24 trials (2051 participants) contributed to individual‐participant analyses. Vitamin D3 daily dose equivalents ranged from 900 to 5000 IU; duration was 4 weeks to 12 months. Trial‐level meta‐analysis showed no significant effect of supplementation on macrovascular measures (flow‐mediated dilatation, 0.37% [95% confidence interval, −0.23 to 0.97]; carotid‐femoral pulse wave velocity, 0.00 m/s [95% confidence interval, −0.36 to 0.37]); similar results were obtained from individual participant data. Microvascular function showed a modest improvement in trial‐level data only. No consistent benefit was observed in subgroup analyses or between different vitamin D analogues. Conclusions Vitamin D supplementation had no significant effect on most markers of vascular function in this analysis.en_US
dc.format.extent21 p.en_US
dc.relation.ispartofseriesJournal of the American Heart Associationen_US
dc.rights© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is noncommercial and no modifications or adaptations are made.en_US
dc.subjectEndothelial Functionen_US
dc.titleEffect of vitamin D supplementation on markers of vascular function : a systematic review and individual participant meta‐analysisen_US
dc.typeJournal Article
dc.contributor.schoolLee Kong Chian School of Medicineen_US
dc.description.versionPublished versionen_US

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