Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/107560
Title: Laser speckle flowgraphy derived characteristics of optic nerve head perfusion in normal tension glaucoma and healthy individuals : a Pilot study
Authors: Mursch-Edlmayr, Anna Sophie
Luft, Nikolaus
Podkowinski, Dominika
Ring, Michael
Schmetterer, Leopold
Bolz, Matthias
Keywords: Normal Tension Glaucoma
Laser Speckle Flowgraphy (LSFG)
Issue Date: 2018
Source: Mursch-Edlmayr, A. S., Luft, N., Podkowinski, D., Ring, M., Schmetterer, L., & Bolz, M. (2018). Laser speckle flowgraphy derived characteristics of optic nerve head perfusion in normal tension glaucoma and healthy individuals : a Pilot study. Scientific Reports, 8(1), 5343-.
Series/Report no.: Scientific Reports
Abstract: The purpose of this prospective, case control study was to investigate the differences in optic nerve head blood flow measured with Laser Speckle Flowgraphy (LSFG) between Caucasian patients with normal tension glaucoma and healthy subjects. It included 20 eyes from 20 Caucasian patients with diagnosis of normal tension glaucoma and 20 eyes from age- and sex-matched healthy individuals. In the glaucoma group the antiglaucomatous therapy was paused 3 weeks prior to the investigations. Measurement of optic nerve head blood flow was performed with LSFG. The mean blur rate was obtained for different vascular compartments of the optic nerve head. Parameters for the characterization of pulse-waveform of the mean blur rate were calculated. It was shown that the mean blur rate was significantly lower in the glaucoma group compared to the control group (P < 0.001). The significant differences in the pulse-waveform parameters blow out time (P=0.028) and flow acceleration time index (P < 0.001) indicate a flatter curve in NTG patients. In conclusion, LSFG can detect differences in optic nerve head blood flow between eyes with normal tension glaucoma and healthy eyes.
URI: https://hdl.handle.net/10356/107560
http://hdl.handle.net/10220/45393
ISSN: 2045-2322
DOI: http://dx.doi.org/10.1038/s41598-018-23149-0
Rights: © 2018 The Author(s) (Nature Publishing Group). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

Google ScholarTM

Check

Altmetric

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.