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Title: Nonstructural proteins of alphavirus—potential targets for drug development
Authors: Abu Bakar, Farhana
Ng, Lisa F. P.
Keywords: Alphavirus Replication
Nonstructural Protein
Issue Date: 2018
Source: Abu Bakar, F., & Ng, L. F. P. (2018). Nonstructural proteins of alphavirus—potential targets for drug development. Viruses, 10(2), 71-.
Series/Report no.: Viruses
Abstract: Alphaviruses are enveloped, positive single-stranded RNA viruses, typically transmitted by arthropods. They often cause arthralgia or encephalitic diseases in infected humans and there is currently no targeted antiviral treatment available. The re-emergence of alphaviruses in Asia, Europe, and the Americas over the last decade, including chikungunya and o’nyong’nyong viruses, have intensified the search for selective inhibitors. In this review, we highlight key molecular determinants within the alphavirus replication complex that have been identified as viral targets, focusing on their structure and functionality in viral dissemination. We also summarize recent structural data of these viral targets and discuss how these could serve as templates to facilitate structure-based drug design and development of small molecule inhibitors.
ISSN: 1999-4915
Rights: © 2018 The Author(s). Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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